130-OR: Effects of Intensive Risk Factor Management on Cardiovascular Autonomic Neuropathy in Type 2 Diabetes: Findings from the ACCORD Trial

130-OR: Effects of Intensive Risk Factor Management on Cardiovascular Autonomic Neuropathy in Type 2 Diabetes: Findings from the ACCORD Trial

Cardiovascular autonomic neuropathy (CAN) is a common complication that independently predicts cardiovascular (CV) morbidity and mortality in persons with type 2 diabetes (T2D). The effect of preventive interventions on CAN remains unclear. We examined the effects of intensively targeting hyperglyce...

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Veröffentlicht in:Diabetes (New York, N.Y.) N.Y.), 2020-06, Vol.69 (Supplement_1)
Hauptverfasser: TANG, YALING, SHAH, HETAL, JUNIOR, CARLOS BUENO, SUN, XIUQIN, MITRI, JOANNA, SAMBATARO, MARIA, SAMBADO, LUISA, GERSTEIN, HERTZEL C., FONSECA, VIVIAN, DORIA, ALESSANDRO, POP-BUSUI, RODICA
Format: Artikel
Sprache:eng
Schlagworte:
Autonomic nervous system
Cardiovascular diseases
Cardiovascular system
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetic neuropathy
Dyslipidemia
Fenofibrate
Glucose monitoring
Heart rate
Hyperglycemia
Metabolic disorders
Morbidity
Risk factors
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Zusammenfassung:Cardiovascular autonomic neuropathy (CAN) is a common complication that independently predicts cardiovascular (CV) morbidity and mortality in persons with type 2 diabetes (T2D). The effect of preventive interventions on CAN remains unclear. We examined the effects of intensively targeting hyperglycemia, hypertension, and dyslipidemia on CAN, in persons with T2D and high CV risk from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. CAN was defined as heart rate variability indices below the 5th percentile of the normal distribution (standard deviation of all normal-to-normal R-R intervals [SDNN]
ISSN:0012-1797
1939-327X
DOI:10.2337/db20-130-OR