864-P: Hyperglycemia Drives Glycemic Variability in Patients with Type 2 Diabetes (T2DM)

We performed quantified glycemic variability using continuous glucose monitoring (CGM) in people with T2DM at high (n=10) or low (n=8) 5-year risk for hypoglycemia to examine if high 5 year risk for hypoglycemia was associated with more short-term (2 weeks) glycemic variability and hypoglycemia. Methods: Participants with T2DM [10W/8M, mean(SD): age: 59.5 (12.3) years], HbA1c: 7.6% (1.3%), fructosamine: 303 (46) umol/l] were preclassified as high or low 5 year risk for hypoglycemia. Each participant wore 2 blinded CGMs (1 Freestyle LibrePro/arm) for 2 weeks. Results: HbA1c and fructosamine did not differ between groups. (Table1) The test/retest coefficient of variation (CV) measures the variation between glucose variability metrics from two sensors on the same person, adjusted for the mean of a given metric. The 2 sensors had the strongest test-re-test (