2301-PUB: The Role of Muramyl Dipeptide in Glucagon-Like Peptide-1 Regulation

2301-PUB: The Role of Muramyl Dipeptide in Glucagon-Like Peptide-1 Regulation

The host’s intestinal microbiota contributes to endocrine and metabolic responses, but a dysbiosis in this environment can lead to obesity and insulin resistance. A new area a research is focused on understanding how bacterial metabolites contribute to intestinal glucagon-like peptide-1 (GLP-1) rele...

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Veröffentlicht in:Diabetes (New York, N.Y.) N.Y.), 2020-06, Vol.69 (Supplement_1)
Hauptverfasser: WILLIAMS, LAURA, ALSHEHRI, AMAL, MUSTAFA, SALMA, GAGNON, JEFFREY
Format: Artikel
Sprache:eng
Schlagworte:
Bacteria
Body weight
Cell walls
Chromium
Diabetes
Dysbacteriosis
Glucagon
Glucagon-like peptide 1
Glucose
Glucose tolerance
Immunohistochemistry
Insulin
Insulin resistance
Intestinal microflora
Intestine
Metabolic disorders
Metabolic response
Metabolism
Metabolites
Microbiota
Muramyl dipeptide
NOD2 protein
Obesity
Peptides
Polymerase chain reaction
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Zusammenfassung:The host’s intestinal microbiota contributes to endocrine and metabolic responses, but a dysbiosis in this environment can lead to obesity and insulin resistance. A new area a research is focused on understanding how bacterial metabolites contribute to intestinal glucagon-like peptide-1 (GLP-1) release. Muramyl dipeptide (MDP) is a bacterial cell wall component which has been shown to improve insulin sensitivity and glucose tolerance in diet-induced obese mice. The purpose of this study was to understand MDP’s mechanism of action in glucose regulation. We hypothesized that MDP enhances glucose tolerance by inducing intestinal GLP-1 secretion. We observed a significant increase (P
ISSN:0012-1797
1939-327X
DOI:10.2337/db20-2301-PUB