Acceleration of an Enzymatic Reaction in Liquid Phase Separated Compartments Based on Intrinsically Disordered Protein Domains

The front cover artwork is provided by the Arosio Lab at ETH Zurich. The image shows liquid phase separated droplets that are based on biologically inspired intrinsically disordered proteins and act as microreactors for enhanced enzymatic reactions. Read the full text of the Article at 10.1002/syst.202000001. “We formed micro‐reactors based on multi‐domain proteins consisting of an enzyme and biologically inspired intrinsically disordered protein domains, which modulate not only the dynamic process of phase separation but also the properties of the resulting compartments, including concentration of enzyme and substrate, polarity and rheological properties. With this modulation we can, in turn, regulate biochemical reactions occurring within the compartments…” This and more about the story behind the front cover can be found in the Article at 10.1002/syst.202000001.