Synthesis and Anticancer Activity of 2-Aryl-3-methylbenzofuro[3,2-b]pyrazolo[4,3-e]azepine-4,11(2H,10H)-dione and 2-Aryl-3,7,9-trimethylpyrido[3',2':4,5]thieno[3,2-b]pyrazolo[4,3-e]azepine-4,11(2H,10H)-diones

The reactions of ethyl 1-aryl-4-(2-bromoacetyl)-5-methyl-1 H -pyrazolocarboxylates with ortho -hydroxybenzonitrile and 4,6-dimethyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile gave previously unknown 2-aryl-3-methylbenzofuro[3,2- b ]pyrazolo[4,3- e ]azepine-4,11(2 H ,10 H )-diones and 2-aryl-3,7,9-trimethylpyrido[3',2':4,5]thieno[3,2- b ]pyrazolo[4,3- e ]azepine-4,11(2 H ,10 H )-diones, respectively. It was found that this reaction occurred as a tandem process. The synthesized compounds were sceened for anticancer activity and exhibited moderate activity against the most part of malignant cancer cells.