Hydroxyurea Dose Escalation for Sickle Cell Anemia in Sub-Saharan Africa

Hydroxyurea Dose Escalation for Sickle Cell Anemia in Sub-Saharan Africa

Hydroxyurea increases expression of fetal hemoglobin and decreases clinical complications in children with sickle cell anemia. A trial of a higher dose (30 mg per kg per day) as compared with a standard dose (20 mg per kg) in children in sub-Saharan Africa showed improved outcomes without increased...

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Veröffentlicht in:The New England journal of medicine 2020-06, Vol.382 (26), p.2524-2533
Hauptverfasser: John, Chandy C, Opoka, Robert O, Latham, Teresa S, Hume, Heather A, Nabaggala, Catherine, Kasirye, Phillip, Ndugwa, Christopher M, Lane, Adam, Ware, Russell E
Format: Artikel
Sprache:eng
Schlagworte:
Anemia
Body weight
Charitable foundations
Children
Clinical trials
Confidence intervals
Dosage
Double-blind studies
Drug dosages
Enrollments
Fetuses
Hemoglobin
Hydroxyurea
Laboratories
Malaria
Medical screening
Neutropenia
Ratios
Safety
Sickle cell anemia
Sickle cell disease
Statistical analysis
Thrombocytopenia
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Zusammenfassung:Hydroxyurea increases expression of fetal hemoglobin and decreases clinical complications in children with sickle cell anemia. A trial of a higher dose (30 mg per kg per day) as compared with a standard dose (20 mg per kg) in children in sub-Saharan Africa showed improved outcomes without increased toxicity.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMoa2000146