Pharmacologic Management of Human Immunodeficiency Virus and Common Chronic Conditions

There has been an evolution in the care and survival of people living with human immunodeficiency virus (PLWH) and AIDS. Increased survival of PLWH is attributed to antiretroviral therapy. However, adverse effects of antiretroviral therapy increase the likelihood that PLWH may also be diagnosed with chronic conditions such as diabetes mellitus, hypertension, and dyslipidemia. Drug-drug interactions are common when coadministering human immunodeficiency virus drugs and therapies for common chronic conditions managed in primary care. To prevent adverse events, nurse practitioners should know about these interactions before prescribing new regimens or modifying a regimen. •People with human immunodeficiency virus (HIV) are living longer due to advances in HIV care.•Adverse effects from antiretroviral therapy increase the likelihood of other chronic conditions.•Drug-drug interactions are common between antiretroviral therapy and medications used for other chronic conditions.•Clinicians should be aware of potential drug interactions when managing HIV and other chronic conditions.