Cutaneous squamous cell carcinoma in a patient with Lynch syndrome

Genetic testing for a germline mutation in the adenomatous polyposis coli gene was negative. Computed tomography of the head and neck revealed a soft-tissue, cutaneous mass in the left side of the lower neck with no underlying extension and multiple cervical lymph nodes. [2] In 2015, Sorscher descri...

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Veröffentlicht in:Indian journal of dermatology, venereology, and leprology venereology, and leprology, 2020-07, Vol.86 (4), p.407-409
Hauptverfasser: Alsukait, Sarah, Almohsen, Zaid, Alqarawi, Sohail, Alsaif, Fahad
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container_title Indian journal of dermatology, venereology, and leprology
container_volume 86
creator Alsukait, Sarah
Almohsen, Zaid
Alqarawi, Sohail
Alsaif, Fahad
description Genetic testing for a germline mutation in the adenomatous polyposis coli gene was negative. Computed tomography of the head and neck revealed a soft-tissue, cutaneous mass in the left side of the lower neck with no underlying extension and multiple cervical lymph nodes. [2] In 2015, Sorscher described a case of a molecularly confirmed germline mutation in MLH-1, along with colon cancer and squamous cell carcinomas, both showing lack of expression of MLH-1, in a 54-year-old man.
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source MEDLINE; Bioline International; EZB-FREE-00999 freely available EZB journals
subjects Adult
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - metabolism
Colonic Neoplasms - metabolism
Colorectal cancer
Colorectal Neoplasms, Hereditary Nonpolyposis - metabolism
DNA-Binding Proteins - metabolism
Family medical history
Female
Gene mutation
Genes
Genetic aspects
Head and Neck Neoplasms - diagnosis
Head and Neck Neoplasms - metabolism
Humans
Immunohistochemistry
Lymphatic system
Mismatch Repair Endonuclease PMS2 - metabolism
Mutation
MutL Protein Homolog 1 - metabolism
MutS Homolog 2 Protein - metabolism
Neck
Neoplasms, Multiple Primary - diagnosis
Neoplasms, Multiple Primary - metabolism
Patients
Skin
Skin cancer
Skin Neoplasms - diagnosis
Skin Neoplasms - metabolism
Squamous cell carcinoma
Tumors
title Cutaneous squamous cell carcinoma in a patient with Lynch syndrome
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