Cutaneous squamous cell carcinoma in a patient with Lynch syndrome

Genetic testing for a germline mutation in the adenomatous polyposis coli gene was negative. Computed tomography of the head and neck revealed a soft-tissue, cutaneous mass in the left side of the lower neck with no underlying extension and multiple cervical lymph nodes. [2] In 2015, Sorscher descri...

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Veröffentlicht in:	Indian journal of dermatology, venereology, and leprology venereology, and leprology, 2020-07, Vol.86 (4), p.407-409
Hauptverfasser:	Alsukait, Sarah, Almohsen, Zaid, Alqarawi, Sohail, Alsaif, Fahad
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - metabolism Colonic Neoplasms - metabolism Colorectal cancer Colorectal Neoplasms, Hereditary Nonpolyposis - metabolism DNA-Binding Proteins - metabolism Family medical history Female Gene mutation Genes Genetic aspects Head and Neck Neoplasms - diagnosis Head and Neck Neoplasms - metabolism Humans Immunohistochemistry Lymphatic system Mismatch Repair Endonuclease PMS2 - metabolism Mutation MutL Protein Homolog 1 - metabolism MutS Homolog 2 Protein - metabolism Neck Neoplasms, Multiple Primary - diagnosis Neoplasms, Multiple Primary - metabolism Patients Skin Skin cancer Skin Neoplasms - diagnosis Skin Neoplasms - metabolism Squamous cell carcinoma Tumors
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Zusammenfassung:	Genetic testing for a germline mutation in the adenomatous polyposis coli gene was negative. Computed tomography of the head and neck revealed a soft-tissue, cutaneous mass in the left side of the lower neck with no underlying extension and multiple cervical lymph nodes. [2] In 2015, Sorscher described a case of a molecularly confirmed germline mutation in MLH-1, along with colon cancer and squamous cell carcinomas, both showing lack of expression of MLH-1, in a 54-year-old man.
ISSN:	0378-6323 0973-3922 1998-3611
DOI:	10.4103/ijdvl.IJDVL_412_19