Loss of sinus compliance, cause of degenerative aortic valve disease, and early failure of biological valves

Loss of compliance of aortic sinuses due to aging or graft replacement causes significant aortic valve leaflet dysfunction. This event leads to stress overload and induces degenerative changes in the patient's (natural or bioprosthetic) valve and unfavorably influences leaflet longevity.

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Veröffentlicht in:Clinical research in cardiology 2000-10, Vol.89 Suppl 7 (S7), p.104-106
Hauptverfasser: Robicsek, F, Thubrikar, M J
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container_title Clinical research in cardiology
container_volume 89 Suppl 7
creator Robicsek, F
Thubrikar, M J
description Loss of compliance of aortic sinuses due to aging or graft replacement causes significant aortic valve leaflet dysfunction. This event leads to stress overload and induces degenerative changes in the patient's (natural or bioprosthetic) valve and unfavorably influences leaflet longevity.
doi_str_mv 10.1007/PL00022878
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identifier ISSN: 0300-5860
ispartof Clinical research in cardiology, 2000-10, Vol.89 Suppl 7 (S7), p.104-106
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source MEDLINE; SpringerLink Journals - AutoHoldings
subjects Aged
Aging
Aging (natural)
Aging - physiology
Aorta
Aortic valve
Aortic Valve - physiology
Aortic Valve - physiopathology
Computer Simulation
Heart Valve Diseases - etiology
Heart valves
Hemodynamics
Humans
Models, Anatomic
Sinus of Valsalva - physiology
Sinuses
Valve leaflets
title Loss of sinus compliance, cause of degenerative aortic valve disease, and early failure of biological valves
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