Loss of sinus compliance, cause of degenerative aortic valve disease, and early failure of biological valves

Loss of sinus compliance, cause of degenerative aortic valve disease, and early failure of biological valves

Loss of compliance of aortic sinuses due to aging or graft replacement causes significant aortic valve leaflet dysfunction. This event leads to stress overload and induces degenerative changes in the patient's (natural or bioprosthetic) valve and unfavorably influences leaflet longevity.

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Bibliographische Detailangaben
Veröffentlicht in:Clinical research in cardiology 2000-10, Vol.89 Suppl 7 (S7), p.104-106
Hauptverfasser: Robicsek, F, Thubrikar, M J
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Aging
Aging (natural)
Aging - physiology
Aorta
Aortic valve
Aortic Valve - physiology
Aortic Valve - physiopathology
Computer Simulation
Heart Valve Diseases - etiology
Heart valves
Hemodynamics
Humans
Models, Anatomic
Sinus of Valsalva - physiology
Sinuses
Valve leaflets
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Beschreibung
Zusammenfassung:Loss of compliance of aortic sinuses due to aging or graft replacement causes significant aortic valve leaflet dysfunction. This event leads to stress overload and induces degenerative changes in the patient's (natural or bioprosthetic) valve and unfavorably influences leaflet longevity.
ISSN:0300-5860
1861-0684
1435-1285
1861-0692
DOI:10.1007/PL00022878