Synthesis and Cytotoxicity of Quinazolin-4(3H)-one Based Peptides

Synthesis and Cytotoxicity of Quinazolin-4(3H)-one Based Peptides

A novel series of quinazolin-4(3 H )-one derivatives has been synthesized in high yields using the multicomponent Ugi reaction and characterized by IR, NMR and mass spectral data. The products have been tested for their cytotoxic activity against HeLa cells. Two tested compounds have shown potent ac...

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Veröffentlicht in:Russian journal of general chemistry 2020-04, Vol.90 (4), p.720-724
Hauptverfasser: Shankaraiah, P., Bhavani, A. K. D., Kumar, A. Kishore, Ramakrishna, K.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Doxorubicin
NMR
Nuclear magnetic resonance
Peptides
Quinones
Reductases
Toxicity
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Zusammenfassung:A novel series of quinazolin-4(3 H )-one derivatives has been synthesized in high yields using the multicomponent Ugi reaction and characterized by IR, NMR and mass spectral data. The products have been tested for their cytotoxic activity against HeLa cells. Two tested compounds have shown potent activity compared to standard drug Doxorubicin. The in silico docking studies of the compounds against quinone reductase-2 (4ZVM) enzyme have also supported their activity.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363220040246