Synthesis, Structure and Biological Activity of Coordination Compounds of Copper, Nickel, Cobalt, and Iron with Ethyl N'-(2-Hydroxybenzylidene)-N-prop-2-en-1-ylcarbamohydrazonothioate
N -(Prop-2-en-1-yl)hydrazonocarbothioamide reacts with iodoethane in methanol with further addition of 2-hydroxybenzaldehyde to form hydroiodide of carbamohydrazonothioate (HL·HI). The coordination compounds were obtained by interaction of HL or HL·HI with copper, nickel, cobalt and iron salts CuLХ·...
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Veröffentlicht in: | Russian journal of general chemistry 2020-04, Vol.90 (4), p.630-639 |
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Hauptverfasser: | , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
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Zusammenfassung: | N
-(Prop-2-en-1-yl)hydrazonocarbothioamide reacts with iodoethane in methanol with further addition of 2-hydroxybenzaldehyde to form hydroiodide of carbamohydrazonothioate (HL·HI). The coordination compounds were obtained by interaction of HL or HL·HI with copper, nickel, cobalt and iron salts CuLХ·
n
H
2
O [X = Cl
–
, Br
–
, NO
3
–
;
n
= 0–1], Ni(L)
2
·HI·CH
3
OH, Сo(L)
2
X [X = I
–
, NO
3
–
] and Fe(L)
2
NO
3
. The structures of three complexes were established by single crystal X-ray analysis. The synthesized complexes exhibit selective antimicrobial and antifungal activity against a series of standard microorganisms and fungi in the concentration range of 30–500 μg/mL. In addition, nickel and iron complexes selectively inhibit the growth and proliferation of cancer cells and do not adversely affect normal cells. |
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ISSN: | 1070-3632 1608-3350 |
DOI: | 10.1134/S107036322004012X |