Amplifying RNA Vaccine Development

There are several strategies to elicit immunity with an RNA vaccine; they all involve coaxing the host cell to replicate and translate an exogenous RNA encoding the vaccine antigen. A recent study describes a new, versatile approach.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2020-06, Vol.382 (25), p.2469-2471
Hauptverfasser:	Fuller, Deborah H, Berglund, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Betacoronavirus - genetics Clinical trials Coronavirus Infections - prevention & control Coronaviruses COVID-19 Deoxyribonucleic acid DNA Gene Amplification Genes Genomes Humans Mice mRNA vaccines Nucleic Acid Amplification Techniques Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - prevention & control Pandemics Pandemics - prevention & control Pathogens Pneumonia, Viral - prevention & control Proteins Ribonucleic acid RNA RNA, Messenger - administration & dosage RNA, Messenger - immunology RNA, Viral - genetics RNA, Viral - physiology RNA-Dependent RNA Polymerase - genetics RNA-Dependent RNA Polymerase - physiology SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Vaccine development Vaccines Viral Vaccines
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Beschreibung
Zusammenfassung:	There are several strategies to elicit immunity with an RNA vaccine; they all involve coaxing the host cell to replicate and translate an exogenous RNA encoding the vaccine antigen. A recent study describes a new, versatile approach.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMcibr2009737