Renin–Angiotensin–Aldosterone System Inhibitors and Risk of Covid-19

There is concern that patients taking renin–angiotensin–aldosterone system inhibitors have an increased risk of Covid-19, because angiotensin-converting enzyme 2 is a receptor for the virus. This study showed no increase in likelihood of a positive Covid-19 test or severe Covid-19 in patients taking...

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Veröffentlicht in:	The New England journal of medicine 2020-06, Vol.382 (25), p.2441-2448
Hauptverfasser:	Reynolds, Harmony R, Adhikari, Samrachana, Pulgarin, Claudia, Troxel, Andrea B, Iturrate, Eduardo, Johnson, Stephen B, Hausvater, Anaïs, Newman, Jonathan D, Berger, Jeffrey S, Bangalore, Sripal, Katz, Stuart D, Fishman, Glenn I, Kunichoff, Dennis, Chen, Yu, Ogedegbe, Gbenga, Hochman, Judith S
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Adrenergic beta-Antagonists - administration & dosage Adrenergic beta-Antagonists - adverse effects Adult Aged Aldosterone Angiotensin Receptor Antagonists - administration & dosage Angiotensin Receptor Antagonists - adverse effects Angiotensin-converting enzyme 2 Angiotensin-converting enzyme inhibitors Angiotensin-Converting Enzyme Inhibitors - administration & dosage Angiotensin-Converting Enzyme Inhibitors - adverse effects Antihypertensive Agents - administration & dosage Antihypertensive Agents - adverse effects Antihypertensives Asthma Bayes Theorem Bayesian analysis Beta blockers Betacoronavirus Binomial distribution Calcium Calcium Channel Blockers - administration & dosage Calcium Channel Blockers - adverse effects Coronavirus Infections - epidemiology Coronaviruses COVID-19 Diabetes Diuretics Female Heart attacks Heart failure Humans Hypertension Hypertension - complications Intensive care Kidney diseases Laboratories Lung diseases Male Mechanical ventilation Medical records Middle Aged New York Pandemics Peptidyl-dipeptidase A Pneumonia, Viral - epidemiology Propensity Score Renin Renin-Angiotensin System - drug effects Risk Factors SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Sodium Chloride Symporter Inhibitors - administration & dosage Sodium Chloride Symporter Inhibitors - adverse effects Ventilators
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Zusammenfassung:	There is concern that patients taking renin–angiotensin–aldosterone system inhibitors have an increased risk of Covid-19, because angiotensin-converting enzyme 2 is a receptor for the virus. This study showed no increase in likelihood of a positive Covid-19 test or severe Covid-19 in patients taking any of five common classes of antihypertensive drugs.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2008975