Two New Isoquinoline Alkaloids from Whole Plants of Thalictrum glandulosissimum and their Anti-TMV Activity

Two New Isoquinoline Alkaloids from Whole Plants of Thalictrum glandulosissimum and their Anti-TMV Activity

Two new isoquinoline alkaloids, 3-hydroxy-1-(7-hydroxy-6-methylisoquinolin-1-yl)propan-1-one ( 1 ) and 3-hydroxy-1-(7-methoxy-6-methylisoquinolin-1-yl)propan-1-one ( 2 ) were isolated from the whole plants of Thalictrum glandulosissimum. Their structures were determined by means of HR-ESI-MS and ext...

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Veröffentlicht in:Chemistry of natural compounds 2020-05, Vol.56 (3), p.500-503
Hauptverfasser: Hu, Qiu-Fen, Liao, Ling-Min, Huang, Hai-Tao, Xu, Yong, Wang, Jin, Kong, Wei-Song, Mi, Qi-Li, Zhou, Min, Yang, Guang-Yu, Song, Chun-Man
Format: Artikel
Sprache:eng
Schlagworte:
Alkaloids
Medicine
NMR
Nuclear magnetic resonance
Organic Chemistry
Pharmacy
Plant Sciences
Tobacco
Viruses
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Zusammenfassung:Two new isoquinoline alkaloids, 3-hydroxy-1-(7-hydroxy-6-methylisoquinolin-1-yl)propan-1-one ( 1 ) and 3-hydroxy-1-(7-methoxy-6-methylisoquinolin-1-yl)propan-1-one ( 2 ) were isolated from the whole plants of Thalictrum glandulosissimum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-tobacco mosaic virus (anti-TMV) activity. The two compounds showed weak anti-TMV activity with inhibition rates of 28.9 and 32.6%. These rates are close to that of positive control.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-020-03071-6