Direct α‐Arylation of Alcohols with Aryl Halides through a Radical Chain Mechanism

Direct α‐Arylation of Alcohols with Aryl Halides through a Radical Chain Mechanism

Alcohols were found to be arylated directly at their α‐C−H bond with aryl halides in the presence of a base and a substoichiometric amount of t‐BuOOt‐Bu through a homolytic aromatic substitution mechanism.

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Veröffentlicht in:Advanced synthesis & catalysis 2020-05, Vol.362 (11), p.2200-2204
Hauptverfasser: Aoki, Kohei, Yonekura, Kyohei, Ikeda, Yuko, Ueno, Ryota, Shirakawa, Eiji
Format: Artikel
Sprache:eng
Schlagworte:
Alcohols
Aromatic compounds
Aromatic substitution
Halides
Hydrogen bonds
Radical reactions
Synthetic methods
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Beschreibung
Zusammenfassung:Alcohols were found to be arylated directly at their α‐C−H bond with aryl halides in the presence of a base and a substoichiometric amount of t‐BuOOt‐Bu through a homolytic aromatic substitution mechanism.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202000216