Zinc Levels and Birth Weight in Pregnant Women with Gestational Diabetes Mellitus: A Matched Cohort Study in China

Abstract Background Zinc (Zn) has been suggested to impact fetal growth. However, the effect may be complicated by gestational diabetes mellitus (GDM) due to its impact on fetal growth and placental transport. This study aims to investigate whether GDM modifies the association between Zn levels and...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2020-07, Vol.105 (7), p.e2337-e2345
Hauptverfasser:	Luo, Jiajun, Wu, Weiwei, Zhang, Ping, Chen, Xi, Feng, Yongliang, Ma, Ning, Yang, Hailan, Wang, Ying, Li, Mei, Xie, Bingjie, Guo, Pengge, Liew, Zeyan, Deziel, Nicole C, Vasiliou, Vasilis, Shi, Xiaoming, Wang, Suping, Zhang, Yawei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Birth weight Birth Weight - physiology Body Mass Index China Cohort analysis Cord blood Diabetes Diabetes mellitus Diabetes, Gestational - blood Diet Dietary intake Female Fetuses Health risk assessment Humans Infant, Newborn Male Placenta Pregnancy Zinc - blood Zinc - deficiency
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Zusammenfassung:	Abstract Background Zinc (Zn) has been suggested to impact fetal growth. However, the effect may be complicated by gestational diabetes mellitus (GDM) due to its impact on fetal growth and placental transport. This study aims to investigate whether GDM modifies the association between Zn levels and birth weight. Method A cohort matched by GDM was established in Taiyuan, China, between 2012 and 2016, including 752 women with GDM and 744 women without. Dietary Zn intake was assessed during pregnancy. Maternal blood (MB) and cord blood (CB) Zn levels were measured at birth. Birth weight was standardized as the z score and categorized as high (HBW, >4000 g) and low (LBW,
ISSN:	0021-972X 1945-7197
DOI:	10.1210/clinem/dgaa171