Synthesis of deuterium-labeled DL-threo-thiamphenicol

A convenient and inexpensive approach for the synthesis of deuterium-labeled thiamphenicol was described. DL - threo -Thiamphenicol-methyl- d 3 was prepared with high chemical purity and isotopic enrichment via a six-step process starting from 4-bromobenzaldehyde and DMSO- d 6 by employing microwave...

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Veröffentlicht in:Journal of radioanalytical and nuclear chemistry 2020-06, Vol.324 (3), p.1463-1467
Hauptverfasser: Zhang, Meihui, Zhang, Lizhi, Wang, Wei, Yan, Tingchang, Xu, Liying, Dong, Jinhua
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Sprache:eng
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Zusammenfassung:A convenient and inexpensive approach for the synthesis of deuterium-labeled thiamphenicol was described. DL - threo -Thiamphenicol-methyl- d 3 was prepared with high chemical purity and isotopic enrichment via a six-step process starting from 4-bromobenzaldehyde and DMSO- d 6 by employing microwave-assisted copper-mediated methylthiolation and modified Wulff’s asymmetric aziridination.
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-020-07155-z