Synthesis of deuterium-labeled DL-threo-thiamphenicol
A convenient and inexpensive approach for the synthesis of deuterium-labeled thiamphenicol was described. DL - threo -Thiamphenicol-methyl- d 3 was prepared with high chemical purity and isotopic enrichment via a six-step process starting from 4-bromobenzaldehyde and DMSO- d 6 by employing microwave...
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Veröffentlicht in: | Journal of radioanalytical and nuclear chemistry 2020-06, Vol.324 (3), p.1463-1467 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | A convenient and inexpensive approach for the synthesis of deuterium-labeled thiamphenicol was described.
DL
-
threo
-Thiamphenicol-methyl-
d
3
was prepared with high chemical purity and isotopic enrichment via a six-step process starting from 4-bromobenzaldehyde and DMSO-
d
6
by employing microwave-assisted copper-mediated methylthiolation and modified Wulff’s asymmetric aziridination. |
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ISSN: | 0236-5731 1588-2780 |
DOI: | 10.1007/s10967-020-07155-z |