Assembly of ruthenium complexes on double stranded DNA using mismatch binding ligands

Herein, we show two new DNA binding small molecules, NCD-RO and NCD-RC , and their ability to bind and selectively assemble ruthenium complexes on G-G mismatch DNA. This study used a naphthyridine carbamate dimer ( NCD ) as an efficient scaffold to assemble metal complexes in a controlled manner on dsDNA. A new molecule containing an NCD moiety and a ruthenium complex was prepared, allowing the assembly of adjoining ruthenium complexes on single dsDNA.