Ingestion of Caustic Substances

Acids and alkalis can cause tissue damage on contact. Accidental and intentional ingestions of caustic materials in adults and children are a worldwide health issue. Acids act in part by denaturing proteins, and alkalis by saponifying fats. Approaches to management are outlined.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2020-04, Vol.382 (18), p.1739-1748
Hauptverfasser:	Hoffman, Robert S, Burns, Michele M, Gosselin, Sophie
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids - adverse effects Adult Age Alkalies - adverse effects Alkalis Burns, Chemical - diagnosis Burns, Chemical - etiology Burns, Chemical - therapy Caustics - history Caustics - poisoning Child Endoscopy, Digestive System Epidemiology Esophageal Perforation - chemically induced Esophageal Perforation - diagnosis Esophageal Stenosis - chemically induced Esophageal Stenosis - diagnosis Esophageal Stenosis - therapy Esophagus Esophagus - diagnostic imaging Fluorides Glucocorticoids - therapeutic use Government Regulation - history History, 20th Century Hospital costs Households Humans Hydrochloric acid Injuries Mitomycin - therapeutic use Pain Poisoning - epidemiology Product Labeling - history Product Labeling - legislation & jurisprudence Public health Public schools Sucralfate - therapeutic use Suicides & suicide attempts United States - epidemiology Vomiting
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Beschreibung
Zusammenfassung:	Acids and alkalis can cause tissue damage on contact. Accidental and intentional ingestions of caustic materials in adults and children are a worldwide health issue. Acids act in part by denaturing proteins, and alkalis by saponifying fats. Approaches to management are outlined.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMra1810769