Characteristics of patients with primary Sjögren’s syndrome associated interstitial lung disease and relevant features of disease progression

Objective To investigate characteristics of patients with primary Sjögren’s syndrome (pSS)-associated interstitial lung disease (ILD) and relevant features of ILD progression. Method Patients with pSS were retrospectively reviewed, and pSS-ILD and pSS non-ILD were identified. Clinical data, laboratory parameters, pulmonary high-resolution CT (HRCT), and pulmonary function tests (PFTs) were collected. pSS-ILD patients were further categorized into subgroups according to HRCT patterns or PFTs. Results Eighty-five pSS-ILD patients and 85 pSS non-ILD patients were included. The average age at disease onset and median disease duration were significantly higher in pSS-ILD patients than those in pSS non-ILD patients ( p