Simulation of the Effect of Point Mutations on the Stability of Protein Dimers Using the Bcl-2 Protein Family as an Example

A new method has been developed that enables synthesizing peptides with desired physicochemical properties, for example, with high affinity to one target protein and low affinity to other proteins, and determining the stability of protein complexes with point substitutions of amino acid residues taking into account the three-dimensional structure of the complex by the example of the Bcl2 family, thereby achieving targeted therapeutic selectivity in the treatment of various pathologies.