Synthesis of 1,3,5-Trisubstituted Pyrazoles and Hydrazones UsingFe3O4@CeO2Nanocomposite as an Efficient Heterogeneous Nanocatalyst

Pyrazoles and hydrazones, as two significant kinds of potentially bioactive compounds, were produced with good to excellent yields by condensation of β-dicarbonyl compounds with hydrazines in aqueous media in the presence of Fe3O4@CeO2 nanocomposite as an efficient heterogeneous nanocatalyst. The magnetic nanocatalyst can readily be separated using an external magnet and reused at least six times without significant loss in activity. The products were characterized by IR and 1H and13C NMR spectra.