Verrucous carcinoma of the upper lip: An exuberant presentation in a patient with other synchronous lesions

Some studies report the association with chronic use of inhaled or chewable tobacco, alcohol and a potential role of human papillomavirus infection, particularly through downregulation of oncosuppressor genes. On the one hand, several studies report prevalence of human papillomavirus in a variable proportion of verrucous carcinoma,[3] while some authors found no association with this infection. The interest of this case is to gather some of the striking features of verrucous carcinoma: the difficulty of diagnosis, the multicentric nature and the lack of pathophysiological determinants such as human papillomavirus infection.