One-Pot Regioselective Synthesis of Some Novel Isoxazole-Phenothiazine Hybrids and Their Antibacterial Activity

Some novel isoxazole-phenothiazine hybrids have been synthesized regioselectively in high yields via Cu(I) catalyzed one-pot reaction of 10-(prop-2-yn-1-yl)phenothiazine with aromatic aldehydes in aqueous butanol medium. Structures of the newly phenothiazine-isoxazole compounds have been confirmed by 1 H and 13 C NMR, and mass spectral data. Products have been evaluated for their antibacterial activity, and few of those demonstrate high growth inhibition activity as compared against the standards drugs Penicillin-G and Streptomycin.