Unbiased Discovery of Dynamic Peptide‐ATP Complexes

The front cover artwork is provided by the groups of Prof. Rein V. Ulijn at CUNY Advanced Science Research Center and Prof. Tell Tuttle at the University of Strathclyde. The image shows adenosine triphosphate, life's ubiquitous energy source, interacting with a short peptide that was discovered using phage display. The formed complexes are dynamic and sample a shallow energy landscape. Read the full text of the Communication at 10.1002/syst.201900013. “Minimalistic peptides are attractive as components for the design of life‐like materials. In a collaborative effort between the CUNY Advanced Science Research Center and the University of Strathclyde, researchers have now demonstrated the unbiased screening for heptapeptides that recognize adenosine triphosphate (ATP), life's ubiquitous energy source. Selected peptides, which were identified using the in vitro method phage display, were found to form complexes with ATP that are highly dynamic and take on an ensemble of conformations along a shallow energy landscape…” This and more about the story behind the front cover can be found in the Communication at 10.1002/syst.201900013.