EFFECTS OF BORIC ACID ON PROINFLAMMATION CYTOKINES, TOTAL OXIDATIVE-ANTIOXIDATIVE STATUS AND HEMATOLOGICAL PARAMETERS IN RATS APPLIED BENZO(a)PYRENE

The aim of this study was to evaluate effects of boric acid (BA) on tumor necrosis factor-alfa (TNF-a), interleukin 1 beta (IL-lB), interleukin-6 (IL-6), total oxidative (TOS)-total anti oxidative status (TAS) and leucocyte (WBC), erythrocyte (RBC), thrombocyte ( PLT) and their other parameters in rats applied benzo(a)pyrene (B(a)P). In this study, rats were divided into 4 groups and each group were containing 6 rats. 1st group was separated as control group. 100 mg/kg total dosage of B(a)P was applied to the 2nd group 2 times a week total in 4 equal dosage with i.p. way. Only BA 300 mg/L was applied to 3Id group in drinking water every day during 150 days. B(a)P was applied twice a week first 2 weeks, 25 mg/kg dose with i.p. way and BA were given with drinking water during 150 days to 4th group. In the end of study was determined TNF-a and IL-lp levels in B(a)P group, increases compared with other groups, there was a statistically significant increase in levels of WBC and LY in group B(a)P+BA compared to other groups (P