FAAH levels and its genetic polymorphism association with susceptibility to methamphetamine dependence

The fatty acid amide hydrolase (FAAH) gene was involved in the modulation of reward and addiction pathophysiology of illicit drugs abuse, and its polymorphisms might be associated with risk of methamphetamine (METH) dependence. This study aimed to investigate the FAAH mRNA levels in peripheral blood...

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Veröffentlicht in:	Annals of human genetics 2020-05, Vol.84 (3), p.259-270
Hauptverfasser:	Zhang, Wei, Liu, Huan, Deng, Xiao‐Dong, Ma, Ying, Liu, Yun
Format:	Artikel
Sprache:	eng
Schlagworte:	Addictions Adult Alleles Amidohydrolases - blood Amidohydrolases - genetics Amphetamine-Related Disorders - genetics Asian Continental Ancestry Group - genetics Case-Control Studies China Drug abuse FAAH Fatty-acid amide hydrolase Female Gene polymorphism Genetic Predisposition to Disease genetic susceptibility Genotype Humans Hydrolase Leukocytes, Mononuclear Male Methamphetamine methamphetamine dependents Middle Aged mRNA Peripheral blood mononuclear cells Polymerase Chain Reaction Polymorphism Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide Protein folding Proteins Reinforcement single‐nucleotide polymorphisms Young Adult
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Zusammenfassung:	The fatty acid amide hydrolase (FAAH) gene was involved in the modulation of reward and addiction pathophysiology of illicit drugs abuse, and its polymorphisms might be associated with risk of methamphetamine (METH) dependence. This study aimed to investigate the FAAH mRNA levels in peripheral blood mononuclear cells and plasma protein levels and to analyze the 385C/A polymorphism (rs324420) between METH‐dependent patients and controls. The levels of FAAH mRNA in METH dependence were significantly lower than in controls (P
ISSN:	0003-4800 1469-1809
DOI:	10.1111/ahg.12368