Semisynthesis of ursolic acid‐2‐(2‐thienylidene)‐oxadiazole hybrid molecule and an evaluation of its COX inhibition property

Semisynthesis of ursolic acid‐2‐(2‐thienylidene)‐oxadiazole hybrid molecule and an evaluation of its COX inhibition property

A new derivative of ursolic acid containing dual functionality was synthesized. Molecular docking studies and in vitro analysis indicated promising COX inhibition potential for the molecule. The synthesis, characterization, in silico and in vitro studies of the molecule are described here.

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Veröffentlicht in:Journal of heterocyclic chemistry 2020-04, Vol.57 (4), p.2048-2055
Hauptverfasser: Deepthi, Ani, Krishnan, Deepa, Sanju, Anuroopa
Format: Artikel
Sprache:eng
Schlagworte:
Chemical synthesis
Chemistry
Chemistry, Organic
Molecular docking
Oxadiazoles
Physical Sciences
Science & Technology
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Zusammenfassung:A new derivative of ursolic acid containing dual functionality was synthesized. Molecular docking studies and in vitro analysis indicated promising COX inhibition potential for the molecule. The synthesis, characterization, in silico and in vitro studies of the molecule are described here.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.3923