New complexes of pectic polysaccharides with nonsteroidal anti-inflammatory drugs

The formation of stable complexes of citrus pectin with nonsteroidal anti-inflammatory drugs, ibuprofen and acetylsalicylic acid (aspirin), was confirmed by IR and NMR spectro scopy. The stoichiometry of complexes with the maximum content of drugs (15 wt. %) was established. A comparative study of t...

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Veröffentlicht in:	Russian chemical bulletin 2020-03, Vol.69 (3), p.572-580
Hauptverfasser:	Chekunkov, Y. V., Minzanova, S. T., Khabibullina, A. V., Arkhipova, D. M., Mironova, L. G., Nemtarev, A. V., Khamatgalimov, A. R., Gubaidullin, A. T., Milyukov, V. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylsalicylic acid Aspirin Chemistry Chemistry and Materials Science Chemistry/Food Science Comparative studies Full Articles Health risk assessment Ibuprofen Inorganic Chemistry NMR Nonsteroidal anti-inflammatory drugs Nuclear magnetic resonance Organic Chemistry Pectin Polysaccharides Stoichiometry Thermal decomposition
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Beschreibung
Zusammenfassung:	The formation of stable complexes of citrus pectin with nonsteroidal anti-inflammatory drugs, ibuprofen and acetylsalicylic acid (aspirin), was confirmed by IR and NMR spectro scopy. The stoichiometry of complexes with the maximum content of drugs (15 wt. %) was established. A comparative study of the thermal decomposition of pectin and the synthesized complexes with ibuprofen and acetylsalicylic acid was performed by TG/DSC.
ISSN:	1066-5285 1573-9171
DOI:	10.1007/s11172-020-2801-z