Short Communication - Prevalence of New Delhi Metallo Beta-Lactamase Producing Gram-Negative Bacteria from Different Tertiary Care Hospitals in Lahore, Pakistan

Short Communication - Prevalence of New Delhi Metallo Beta-Lactamase Producing Gram-Negative Bacteria from Different Tertiary Care Hospitals in Lahore, Pakistan

ABSTRACT Carbapenem resistance conferred by metallo-β-lactamase (MBL) has increasingly being reported worldwide among Enterobacteriaceae. In this study, 240 non repetitive gram negative clinical isolates were studied for antimicrobial resistance. Presence of bla NDM was determined by polymerase chai...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Pakistan journal of zoology 2020-06, Vol.52 (3), p.1209
Hauptverfasser: Rashid, Farzana, Masood, Rabia, Faiz, Mariam
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Anopheles
Antibiotics
Antimicrobial resistance
Bacteria
Bacterial infections
Beta lactamases
Carbapenems
Clinical isolates
Cross infection
Dosage and administration
Drug resistance
Drug therapy
E coli
Enzymes
Gram-negative bacteria
Gram-negative bacterial infections
Hospital patients
Hospitals
Hydrolysis
Imipenem
Indicator species
Infection
Laboratories
Lactams
Meropenem
Metallo-β-lactamase
Metallography
Microbial drug resistance
Nosocomial infections
Polymerase chain reaction
Prevalence studies (Epidemiology)
Safety and security measures
Setting (Literature)
Strains (organisms)
β Lactamase
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:ABSTRACT Carbapenem resistance conferred by metallo-β-lactamase (MBL) has increasingly being reported worldwide among Enterobacteriaceae. In this study, 240 non repetitive gram negative clinical isolates were studied for antimicrobial resistance. Presence of bla NDM was determined by polymerase chain reaction. Among 240 strains, prevalence of MBL in K. pneumoniae, P. aeruginosa, E. coli and Acinetobacter Species was 26%, 52%, 27% and 5% respectively. Prevalence of blaNDM-1 gene was 51% identified in 14 strains of P. aeruginosa, 2 strains of A. Baumanni, 29 strains of E. coli and 18 strains of K. pneumoniae. In conclusion, high prevalence of blaNDM-1 in our strains is a serious concern. A careful use of carbapenems is important to prevent the spread of these organisms.
ISSN:0030-9923