DBSA‐Catalyzed Regioselective Dehydrative Friedel‐Crafts Arylation of CF3‐Containing 3‐Indolyl(2‐thiophenyl)methanols with 2‐Substituted Indoles in Water

DBSA‐Catalyzed Regioselective Dehydrative Friedel‐Crafts Arylation of CF3‐Containing 3‐Indolyl(2‐thiophenyl)methanols with 2‐Substituted Indoles in Water

A green and efficient regioselective dehydrative Friedel‐Crafts arylation of trifluorinated 3‐indolyl(2‐thiophenyl) methanols with 2‐substituted indoles, catalyzed by DBSA (dodecylbenzenesulfonic acid) in water is described. This simple and atom‐economical protocol features a unique regioselective 1...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Advanced synthesis & catalysis 2020-04, Vol.362 (7), p.1514-1524
Hauptverfasser: An, Di, Miao, Xinzhu, Ling, Xiangxiang, Chen, Xianxiao, Rao, Weidong
Format: Artikel
Sprache:eng
Schlagworte:
1,8-Addition
3-Indolyl(2-thiophenyl) methanols
DBSA
Dehydration
Dehydrative Friedel-Crafts
Friedel-Crafts reaction
Functional groups
Indole
Indoles
Regioselectivity
Sodium dodecylbenzenesulfonate
Substitutes
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A green and efficient regioselective dehydrative Friedel‐Crafts arylation of trifluorinated 3‐indolyl(2‐thiophenyl) methanols with 2‐substituted indoles, catalyzed by DBSA (dodecylbenzenesulfonic acid) in water is described. This simple and atom‐economical protocol features a unique regioselective 1,8‐addition, operational simplicity, mild conditions, excellent functional group compatibility, and environmental benignity.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202000020