Catalytic cycloalumination of 1,2-dienes in the total synthesis of natural grenadamide and lyngbyoic acid

Catalytic cycloalumination of 1,2-dienes in the total synthesis of natural grenadamide and lyngbyoic acid

An original method for the total synthesis of natural grenadamide and its precursor lyngbyoic acid with high stereoselectivity and yields was developed using the catalytic cycloalumination reaction of 1,2-dienes with Et 3 Al in the presence of 5 mol.% of Cp 2 ZrCl 2 (Dzhemilev reaction) as a key ste...

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Veröffentlicht in:Russian chemical bulletin 2020-02, Vol.69 (2), p.386-389
Hauptverfasser: D´yakonov, V. A., Makarov, A. A., Andreev, E. N., Makarova, E. Kh, Dzhemileva, L. U., Khalilov, L. M., Dzhemilev, U. M.
Format: Artikel
Sprache:eng
Schlagworte:
Brief Communication
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Dienes
Inorganic Chemistry
Organic Chemistry
Stereoselectivity
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Beschreibung
Zusammenfassung:An original method for the total synthesis of natural grenadamide and its precursor lyngbyoic acid with high stereoselectivity and yields was developed using the catalytic cycloalumination reaction of 1,2-dienes with Et 3 Al in the presence of 5 mol.% of Cp 2 ZrCl 2 (Dzhemilev reaction) as a key step.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-020-2772-0