Telacebec (Q203), a New Antituberculosis Agent

Telacebec (Q203), a New Antituberculosis Agent

Telacebec (Q203) is a novel drug that targets Mycobacterium tuberculosis cellular energy production through inhibition of the mycobacterial cytochrome bc1 complex. This proof-of-concept study evaluated the bactericidal activity of telacebec over a period of 14 days in patients with newly diagnosed,...

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Veröffentlicht in:The New England journal of medicine 2020-03, Vol.382 (13), p.1280-1281
Hauptverfasser: de Jager, Veronique R, Dawson, Rodney, van Niekerk, Christo, Hutchings, Jane, Kim, Jeongjun, Vanker, Naadira, van der Merwe, Lize, Choi, Jinho, Nam, Kiyean, Diacon, Andreas H
Format: Artikel
Sprache:eng
Schlagworte:
Bactericidal activity
Cytochrome bc1
Drug dosages
Drug resistance
Tuberculosis
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Zusammenfassung:Telacebec (Q203) is a novel drug that targets Mycobacterium tuberculosis cellular energy production through inhibition of the mycobacterial cytochrome bc1 complex. This proof-of-concept study evaluated the bactericidal activity of telacebec over a period of 14 days in patients with newly diagnosed, drug-susceptible pulmonary tuberculosis.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMc1913327