Arterial stiffness and matrix metalloproteinases: A correlation study in hypertensive type 2 diabetic subjects

Arterial stiffness and matrix metalloproteinases: A correlation study in hypertensive type 2 diabetic subjects

Introduction Matrix metalloproteinases (MMP’s) and tribbles 3 human homolog (Trb3) are implicated in atherosclerosis. Changes in the concentration of these biomolecules signal the risk of atherosclerosis in type 2 subjects (T2DM), with or without hypertension (HT), at an early stage. Aim Our aim was...

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Veröffentlicht in:International journal of diabetes in developing countries 2020-03, Vol.40 (1), p.106-113
Hauptverfasser: Ratnaparkhi, Prashant Shirish, Kulkarni, Namrata Bindurao, Ganu, Meghana Ulhas, Godbole, Sanjay Ganesh, Deo, Sudha Shrikant
Format: Artikel
Sprache:eng
Schlagworte:
Ankle
Arteriosclerosis
Atherosclerosis
Diabetes
Diabetes mellitus
Endocrinology & Metabolism
Family Medicine
Gelatinase A
Gelatinase B
General Practice
Health Administration
Life Sciences & Biomedicine
Matrix metalloproteinase
Medicine
Medicine & Public Health
Original Article
Science & Technology
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Zusammenfassung:Introduction Matrix metalloproteinases (MMP’s) and tribbles 3 human homolog (Trb3) are implicated in atherosclerosis. Changes in the concentration of these biomolecules signal the risk of atherosclerosis in type 2 subjects (T2DM), with or without hypertension (HT), at an early stage. Aim Our aim was to assess the relation between noninvasive arterial stiffness indices and circulating levels of MMP2, MMP9 and Trb3. Methodology The study included 144 participants divided into 4 groups: T2DM > 5 years + HT, DM + HT ( n  = 55), T2DM 
ISSN:0973-3930
1998-3832
DOI:10.1007/s13410-019-00727-0