Calcium channel blockers and Alzheimer＇s disease

Calcium channel blockers and Alzheimer＇s disease

Alzheimer＇s disease is characterized by two pathological hallmarks： amyloid plaques and neurofibrillary tangles. In addition, calcium homeostasis is disrupted in the course of human aging Recent research shows that dense plaques can cause functional alteration of calcium signals in mice with Alzheim...

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Veröffentlicht in:Neural regeneration research 2012, Vol.7 (2), p.137-140
Hauptverfasser: Tan, Yi, Deng, Yulin, Hong, Qing
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine triphosphate
Alzheimer's disease
Brain research
Drugs
Homeostasis
Kinases
Mitochondria
Pathogenesis
Permeability
Plasma
Proteins
原纤维
病理特征
衰老过程
钙离子通道
钙通道阻滞剂
阿尔茨海默氏病
阿尔茨海默氏症
阿尔茨海默病
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Zusammenfassung:Alzheimer＇s disease is characterized by two pathological hallmarks： amyloid plaques and neurofibrillary tangles. In addition, calcium homeostasis is disrupted in the course of human aging Recent research shows that dense plaques can cause functional alteration of calcium signals in mice with Alzheimer＇s disease. Calcium channel blockers are effective therapeutics for treating Alzheimer＇s disease. This review provides an overview of the current research of calcium channel blockers involved in Alzheimer＇s disease theraov.
ISSN:1673-5374
1876-7958