4CPS-196 Stability of lipid emulsion in paediatric parenteral nutrition with high electrolytic load
Background and importanceTernary mixtures in parenteral nutrition (PN) have a complex composition and so interactions between components can lead to instability, compromising safety. Fat globules >5 µm can cause thromboembolisms. Critical aggregation number (CAN) is used to predict stability (cal...
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| Veröffentlicht in: | European journal of hospital pharmacy. Science and practice 2020-03, Vol.27 (Suppl 1), p.A140-A140 |
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| container_title | European journal of hospital pharmacy. Science and practice |
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| creator | Otero Millan, L Lago Rivero, N Legido Soto, JL Vázquez López, C Blanco Rodicio, A Piñeiro Corrales, G |
| description | Background and importanceTernary mixtures in parenteral nutrition (PN) have a complex composition and so interactions between components can lead to instability, compromising safety. Fat globules >5 µm can cause thromboembolisms. Critical aggregation number (CAN) is used to predict stability (calculated with cation concentration).Aim and objectivesTo analyse the stability of the lipid emulsion in PN samples with a high CAN using globule size measurements, and to evaluate the influence of temperature and time on emulsion stability.Material and methodsWe studied four samples according to the nutritional requirements of a 1 kg neonate during the first days of life. Micronutrient amounts were greater than those recommended, and vitamins and zinc were also added. Samples were prepared in duplicate.Globule size was measured by laser diffraction (Beckman Coulter LS-I3-320) on the preparation day (day 0) and after 7 days. The samples were stored under refrigerated conditions and at room temperature. CAN was calculated based on the concentrations of cations present in each PN. Statistical analysis was performed using the Student’s t test (statistical significance p |
| doi_str_mv | 10.1136/ejhpharm-2020-eahpconf.297 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_bmj_p</sourceid><recordid>TN_cdi_proquest_journals_2382407591</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2382407591</sourcerecordid><originalsourceid>FETCH-LOGICAL-b1267-1022c14b2273567862b80ab8df72572db1acf83804f31b389b9e8408d2bf88d13</originalsourceid><addsrcrecordid>eNo9kMtKxDAUhoMoOOi8Q9B1xtzaJEsZvMGAwug6JG1qM6QX0xSZnRtf1CexZRxX5-fw8R_OB8AVwStCWH7jdnVfm9ggiilGztR90bXViipxAhYUc4GUyvnpf87yc7AcBm9xxphUnKkFcHz9skVE5T9f39tkrA8-7WFXweB7X0LXjGHwXQt9C3vjSm9S9MUUo2uTiybAdpw2aUY-faph7d9r6IIrUuzCPk1s6Ex5Cc4qEwa3_JsX4O3-7nX9iDbPD0_r2w2yhOYCEUxpQbilVLAsFzKnVmJjZVkJmglaWmKKSjKJecWInV6wykmOZUltJWVJ2AW4PvT2sfsY3ZD0rhtjO53UlEnKscjUTGUHyjY73UffmLjXBOtZqj5K1bNUfZSqJ6nsF7OvcLE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2382407591</pqid></control><display><type>article</type><title>4CPS-196 Stability of lipid emulsion in paediatric parenteral nutrition with high electrolytic load</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Otero Millan, L ; Lago Rivero, N ; Legido Soto, JL ; Vázquez López, C ; Blanco Rodicio, A ; Piñeiro Corrales, G</creator><creatorcontrib>Otero Millan, L ; Lago Rivero, N ; Legido Soto, JL ; Vázquez López, C ; Blanco Rodicio, A ; Piñeiro Corrales, G</creatorcontrib><description>Background and importanceTernary mixtures in parenteral nutrition (PN) have a complex composition and so interactions between components can lead to instability, compromising safety. Fat globules >5 µm can cause thromboembolisms. Critical aggregation number (CAN) is used to predict stability (calculated with cation concentration).Aim and objectivesTo analyse the stability of the lipid emulsion in PN samples with a high CAN using globule size measurements, and to evaluate the influence of temperature and time on emulsion stability.Material and methodsWe studied four samples according to the nutritional requirements of a 1 kg neonate during the first days of life. Micronutrient amounts were greater than those recommended, and vitamins and zinc were also added. Samples were prepared in duplicate.Globule size was measured by laser diffraction (Beckman Coulter LS-I3-320) on the preparation day (day 0) and after 7 days. The samples were stored under refrigerated conditions and at room temperature. CAN was calculated based on the concentrations of cations present in each PN. Statistical analysis was performed using the Student’s t test (statistical significance p<0.05).ResultsPN composition is shown in table 1 and average globule size (µm) is shown in table 2.Abstract 4CPS-196 Table 1 Sample (100 mL) Nitrogen (g/L) Glucose (g/L) Lipids (g/L) Sodium (mmol/L) Potassium (mmol/L) Magnesium (mmol/L) Calcium (mmol/L) Phosphorus (mmol/L) CAN (mmol/L) PN1 3.7 92.6 17.5 40.0 30.0 3.0 20.0 20.0 1542 PN2 4.2 106.8 21.6 40.0 30.0 3.0 20.0 20.0 1542 PN3 4.7 121.0 25.8 50.0 35.0 3.5 22.5 25.0 1749 PN4 5.2 135.2 29.9 60.0 40.0 4.0 25.0 30.0 1956 Abstract 4CPS-196 Table 2 Sample Day 0 Day 7 (25°C) Day 7 (4°C) PN1 0.251±0.086 0.263±0.099 0.244±0.081 PN2 0.269±0.115 0.248±0.086 0.257±0.095 PN3 0.266±0.098 0.268±0.112 0.270±0.102 PN4 0.270±0.101 0.273±0.111 0.257±0.082 There were no significant differences between measurements on day 0 and day 7 on samples stored at room temperature or in a refrigerator (p=0.896 and p=0.171, respectively).Conclusion and relevanceAverage globule size was stable despite a high CAN of samples, but more sensitive analytical techniques may be necessary to detect changes in the fraction of large globules. The study time and different storage temperature did not influence the average globule size of our samples. To establish the overall stability of the PN, more complete studies should be carried out, analysing more stability dependent processes.References and/or acknowledgementsNo conflict of interest.</description><identifier>ISSN: 2047-9956</identifier><identifier>EISSN: 2047-9964</identifier><identifier>DOI: 10.1136/ejhpharm-2020-eahpconf.297</identifier><language>eng</language><publisher>London: BMJ Publishing Group LTD</publisher><subject>Parenteral nutrition</subject><ispartof>European journal of hospital pharmacy. Science and practice, 2020-03, Vol.27 (Suppl 1), p.A140-A140</ispartof><rights>Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2020 Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Otero Millan, L</creatorcontrib><creatorcontrib>Lago Rivero, N</creatorcontrib><creatorcontrib>Legido Soto, JL</creatorcontrib><creatorcontrib>Vázquez López, C</creatorcontrib><creatorcontrib>Blanco Rodicio, A</creatorcontrib><creatorcontrib>Piñeiro Corrales, G</creatorcontrib><title>4CPS-196 Stability of lipid emulsion in paediatric parenteral nutrition with high electrolytic load</title><title>European journal of hospital pharmacy. Science and practice</title><description>Background and importanceTernary mixtures in parenteral nutrition (PN) have a complex composition and so interactions between components can lead to instability, compromising safety. Fat globules >5 µm can cause thromboembolisms. Critical aggregation number (CAN) is used to predict stability (calculated with cation concentration).Aim and objectivesTo analyse the stability of the lipid emulsion in PN samples with a high CAN using globule size measurements, and to evaluate the influence of temperature and time on emulsion stability.Material and methodsWe studied four samples according to the nutritional requirements of a 1 kg neonate during the first days of life. Micronutrient amounts were greater than those recommended, and vitamins and zinc were also added. Samples were prepared in duplicate.Globule size was measured by laser diffraction (Beckman Coulter LS-I3-320) on the preparation day (day 0) and after 7 days. The samples were stored under refrigerated conditions and at room temperature. CAN was calculated based on the concentrations of cations present in each PN. Statistical analysis was performed using the Student’s t test (statistical significance p<0.05).ResultsPN composition is shown in table 1 and average globule size (µm) is shown in table 2.Abstract 4CPS-196 Table 1 Sample (100 mL) Nitrogen (g/L) Glucose (g/L) Lipids (g/L) Sodium (mmol/L) Potassium (mmol/L) Magnesium (mmol/L) Calcium (mmol/L) Phosphorus (mmol/L) CAN (mmol/L) PN1 3.7 92.6 17.5 40.0 30.0 3.0 20.0 20.0 1542 PN2 4.2 106.8 21.6 40.0 30.0 3.0 20.0 20.0 1542 PN3 4.7 121.0 25.8 50.0 35.0 3.5 22.5 25.0 1749 PN4 5.2 135.2 29.9 60.0 40.0 4.0 25.0 30.0 1956 Abstract 4CPS-196 Table 2 Sample Day 0 Day 7 (25°C) Day 7 (4°C) PN1 0.251±0.086 0.263±0.099 0.244±0.081 PN2 0.269±0.115 0.248±0.086 0.257±0.095 PN3 0.266±0.098 0.268±0.112 0.270±0.102 PN4 0.270±0.101 0.273±0.111 0.257±0.082 There were no significant differences between measurements on day 0 and day 7 on samples stored at room temperature or in a refrigerator (p=0.896 and p=0.171, respectively).Conclusion and relevanceAverage globule size was stable despite a high CAN of samples, but more sensitive analytical techniques may be necessary to detect changes in the fraction of large globules. The study time and different storage temperature did not influence the average globule size of our samples. To establish the overall stability of the PN, more complete studies should be carried out, analysing more stability dependent processes.References and/or acknowledgementsNo conflict of interest.</description><subject>Parenteral nutrition</subject><issn>2047-9956</issn><issn>2047-9964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNo9kMtKxDAUhoMoOOi8Q9B1xtzaJEsZvMGAwug6JG1qM6QX0xSZnRtf1CexZRxX5-fw8R_OB8AVwStCWH7jdnVfm9ggiilGztR90bXViipxAhYUc4GUyvnpf87yc7AcBm9xxphUnKkFcHz9skVE5T9f39tkrA8-7WFXweB7X0LXjGHwXQt9C3vjSm9S9MUUo2uTiybAdpw2aUY-faph7d9r6IIrUuzCPk1s6Ex5Cc4qEwa3_JsX4O3-7nX9iDbPD0_r2w2yhOYCEUxpQbilVLAsFzKnVmJjZVkJmglaWmKKSjKJecWInV6wykmOZUltJWVJ2AW4PvT2sfsY3ZD0rhtjO53UlEnKscjUTGUHyjY73UffmLjXBOtZqj5K1bNUfZSqJ6nsF7OvcLE</recordid><startdate>202003</startdate><enddate>202003</enddate><creator>Otero Millan, L</creator><creator>Lago Rivero, N</creator><creator>Legido Soto, JL</creator><creator>Vázquez López, C</creator><creator>Blanco Rodicio, A</creator><creator>Piñeiro Corrales, G</creator><general>BMJ Publishing Group LTD</general><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>202003</creationdate><title>4CPS-196 Stability of lipid emulsion in paediatric parenteral nutrition with high electrolytic load</title><author>Otero Millan, L ; Lago Rivero, N ; Legido Soto, JL ; Vázquez López, C ; Blanco Rodicio, A ; Piñeiro Corrales, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b1267-1022c14b2273567862b80ab8df72572db1acf83804f31b389b9e8408d2bf88d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Parenteral nutrition</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Otero Millan, L</creatorcontrib><creatorcontrib>Lago Rivero, N</creatorcontrib><creatorcontrib>Legido Soto, JL</creatorcontrib><creatorcontrib>Vázquez López, C</creatorcontrib><creatorcontrib>Blanco Rodicio, A</creatorcontrib><creatorcontrib>Piñeiro Corrales, G</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>European journal of hospital pharmacy. Science and practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Otero Millan, L</au><au>Lago Rivero, N</au><au>Legido Soto, JL</au><au>Vázquez López, C</au><au>Blanco Rodicio, A</au><au>Piñeiro Corrales, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>4CPS-196 Stability of lipid emulsion in paediatric parenteral nutrition with high electrolytic load</atitle><jtitle>European journal of hospital pharmacy. Science and practice</jtitle><date>2020-03</date><risdate>2020</risdate><volume>27</volume><issue>Suppl 1</issue><spage>A140</spage><epage>A140</epage><pages>A140-A140</pages><issn>2047-9956</issn><eissn>2047-9964</eissn><abstract>Background and importanceTernary mixtures in parenteral nutrition (PN) have a complex composition and so interactions between components can lead to instability, compromising safety. Fat globules >5 µm can cause thromboembolisms. Critical aggregation number (CAN) is used to predict stability (calculated with cation concentration).Aim and objectivesTo analyse the stability of the lipid emulsion in PN samples with a high CAN using globule size measurements, and to evaluate the influence of temperature and time on emulsion stability.Material and methodsWe studied four samples according to the nutritional requirements of a 1 kg neonate during the first days of life. Micronutrient amounts were greater than those recommended, and vitamins and zinc were also added. Samples were prepared in duplicate.Globule size was measured by laser diffraction (Beckman Coulter LS-I3-320) on the preparation day (day 0) and after 7 days. The samples were stored under refrigerated conditions and at room temperature. CAN was calculated based on the concentrations of cations present in each PN. Statistical analysis was performed using the Student’s t test (statistical significance p<0.05).ResultsPN composition is shown in table 1 and average globule size (µm) is shown in table 2.Abstract 4CPS-196 Table 1 Sample (100 mL) Nitrogen (g/L) Glucose (g/L) Lipids (g/L) Sodium (mmol/L) Potassium (mmol/L) Magnesium (mmol/L) Calcium (mmol/L) Phosphorus (mmol/L) CAN (mmol/L) PN1 3.7 92.6 17.5 40.0 30.0 3.0 20.0 20.0 1542 PN2 4.2 106.8 21.6 40.0 30.0 3.0 20.0 20.0 1542 PN3 4.7 121.0 25.8 50.0 35.0 3.5 22.5 25.0 1749 PN4 5.2 135.2 29.9 60.0 40.0 4.0 25.0 30.0 1956 Abstract 4CPS-196 Table 2 Sample Day 0 Day 7 (25°C) Day 7 (4°C) PN1 0.251±0.086 0.263±0.099 0.244±0.081 PN2 0.269±0.115 0.248±0.086 0.257±0.095 PN3 0.266±0.098 0.268±0.112 0.270±0.102 PN4 0.270±0.101 0.273±0.111 0.257±0.082 There were no significant differences between measurements on day 0 and day 7 on samples stored at room temperature or in a refrigerator (p=0.896 and p=0.171, respectively).Conclusion and relevanceAverage globule size was stable despite a high CAN of samples, but more sensitive analytical techniques may be necessary to detect changes in the fraction of large globules. The study time and different storage temperature did not influence the average globule size of our samples. To establish the overall stability of the PN, more complete studies should be carried out, analysing more stability dependent processes.References and/or acknowledgementsNo conflict of interest.</abstract><cop>London</cop><pub>BMJ Publishing Group LTD</pub><doi>10.1136/ejhpharm-2020-eahpconf.297</doi><oa>free_for_read</oa></addata></record> |
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| title | 4CPS-196 Stability of lipid emulsion in paediatric parenteral nutrition with high electrolytic load |
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