Click Synthesis of 1,2,3-Triazole Nucleosides Based on Functionalized Nicotinonitriles
A facile synthesis of a new series of 1,2,3-triazolyl nucleosides via one-pot click reaction is described. Acetylenic nicotinonitriles synthesized previously by alkylation of 4,6-diaryl-2-oxonicotinonitriles with propargyl bromide were involved in cycloaddition with 2,3,4,6-tetra- O -acetyl-D-glucop...
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Veröffentlicht in: | Russian journal of organic chemistry 2020, Vol.56 (1), p.143-147 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | A facile synthesis of a new series of 1,2,3-triazolyl nucleosides via one-pot click reaction is described. Acetylenic nicotinonitriles synthesized previously by alkylation of 4,6-diaryl-2-oxonicotinonitriles with propargyl bromide were involved in cycloaddition with 2,3,4,6-tetra-
O
-acetyl-D-glucopyranosyl azide in the presence of copper(I) to afford 1,2,3-triazole derivatives which were deprotected by treatment with aqueous triethylamine. The obtained 1,2,3-triazole nucleosides showed significant antimicrobial activities against some Gram-positive and Gram-negative bacteria and fungi. |
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ISSN: | 1070-4280 1608-3393 |
DOI: | 10.1134/S1070428020010224 |