Click Synthesis of 1,2,3-Triazole Nucleosides Based on Functionalized Nicotinonitriles

A facile synthesis of a new series of 1,2,3-triazolyl nucleosides via one-pot click reaction is described. Acetylenic nicotinonitriles synthesized previously by alkylation of 4,6-diaryl-2-oxonicotinonitriles with propargyl bromide were involved in cycloaddition with 2,3,4,6-tetra- O -acetyl-D-glucop...

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Veröffentlicht in:Russian journal of organic chemistry 2020, Vol.56 (1), p.143-147
Hauptverfasser: Morsy, H. A., Mohammed, S. M., Abdel Hamid, A. M., Moustafa, A. H., El-Sayed, H. A.
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Sprache:eng
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Zusammenfassung:A facile synthesis of a new series of 1,2,3-triazolyl nucleosides via one-pot click reaction is described. Acetylenic nicotinonitriles synthesized previously by alkylation of 4,6-diaryl-2-oxonicotinonitriles with propargyl bromide were involved in cycloaddition with 2,3,4,6-tetra- O -acetyl-D-glucopyranosyl azide in the presence of copper(I) to afford 1,2,3-triazole derivatives which were deprotected by treatment with aqueous triethylamine. The obtained 1,2,3-triazole nucleosides showed significant antimicrobial activities against some Gram-positive and Gram-negative bacteria and fungi.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428020010224