Synthesis, Application, and Properties of Bis(1H-azol-1-yl)methanimines

Synthesis, Application, and Properties of Bis(1H-azol-1-yl)methanimines

The review considers methods of preparation and application of bis(1 H -azol-1-yl)methanimines that are imino analogs of 1,1′-carbonylbisazoles widely used in the synthesis of various organic compounds, including natural ones. Methods of synthesis of a number of new symmetrical and unsymmetrical bis...

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Veröffentlicht in:Russian journal of organic chemistry 2020, Vol.56 (1), p.105-112
Hauptverfasser: Purygin, P. P., Zarubin, Yu. P.
Format: Artikel
Sprache:eng
Schlagworte:
Biological activity
Carbonyls
Chemistry
Chemistry and Materials Science
Erythrocytes
Imidazole
Organic Chemistry
Organic compounds
Review
Synthesis
Tetrahydrofuran
Triazoles
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Zusammenfassung:The review considers methods of preparation and application of bis(1 H -azol-1-yl)methanimines that are imino analogs of 1,1′-carbonylbisazoles widely used in the synthesis of various organic compounds, including natural ones. Methods of synthesis of a number of new symmetrical and unsymmetrical bisazolylmethanimines derived from imidazole, 2(4)-alkylimidazoles, and 1,2,4-triazole are described, and data on their hydrolytic stability in aqueous—organic medium (aqueous tetrahydrofuran) at 25°C and pH 7 and biological activity with respect to rat erythrocytes are given.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428020010170