Synthesis and Cytotoxic Activity of a Number of Functionalized 2,3-Allenoates

Synthesis and Cytotoxic Activity of a Number of Functionalized 2,3-Allenoates

A series of new functionalized allenoates has been synthesized, and their cytotoxic effect has been studied against the tumor cell line (HepG2 and Jurkat) and the normal origin cells (HEK293). The highest cytotoxic effect has been shown for diterpene-containing allenic compounds, which can be attrib...

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Veröffentlicht in:Russian journal of bioorganic chemistry 2020, Vol.46 (1), p.115-119
Hauptverfasser: Malikova, R. N., Sakhautdinov, I. M., Maksimova, M. A., Kuzmina, U. Sh, Vakhitova, Yu. V., Yunusov, M. S.
Format: Artikel
Sprache:eng
Schlagworte:
Anticancer properties
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Cytotoxicity
Life Sciences
Organic Chemistry
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Zusammenfassung:A series of new functionalized allenoates has been synthesized, and their cytotoxic effect has been studied against the tumor cell line (HepG2 and Jurkat) and the normal origin cells (HEK293). The highest cytotoxic effect has been shown for diterpene-containing allenic compounds, which can be attributed to promising substances with potential antitumor activity.
ISSN:1068-1620
1608-330X
DOI:10.1134/S1068162020010057