Comparative In Silico drug likeness and In vitro study of some Schiff's bases as potent COX-II Inhibitors

Molecular properties include molecular weight, electronic distribution, hydrophobicity, hydrogen bond donors/acceptors, solubility, viscosity, excess volume and other related properties. Lipinski's "rule of five" predicts drug-likeness on the basis of various molecular descriptors Milog P, n violations, molecular mass, n rotb No. hydrogen bond donors and No. hydrogen bond acceptor, Bioactivity score2. [...]inhibition of albumin denaturation technique was studied, a 5.0ml reaction mixture was prepared consisting of 0.2ml of egg albumin (obtained from fresh hen's egg), 2.8ml phosphate buffered saline (pH: 6.4) and 2.0ml of varying concentration of test compounds so that final concentrations become 25, 50, 100, 200pg/ml. IR spectra (KBr pellets) were recorded on Shimadzu FT-IR model 8010 spectrophotometer. Ш NMR spectra (DMSO-d6) were taken a Varian mercury spectrometer (model YH- 300 FT NMR) using Tetramethyl Silane (TMS) as internal standard and chemical shift are expressed in 5 ppm.