Formulation and Evaluation of Trifluoperazine HCl as rectal suppositories by using different types of surfactants in Cocoa butter

[...]different drugs can be loaded in rectal suppositories for treatment of nausea, vomiting, inflammation of bowel and hemorrhoids [4], Additionally, it was noticeable, the growing interest in formulating painkillers by using suppositories such as the morphine suppository to control the pain of anal cancer patients [5]. [...]many studies showed the importance of painkiller suppositories for pre or postoperative patients like Lee et al reveled a reduced in pain for patients of prior ureteroscopy by using opium rectal suppository [6], and opium suppository in a different study was used for patients undergoing the laparoscopic hysterectomy operation [7]. [...]Jones et al formulated prochlorperazine as rectal suppository and their formulation showed within 2 hours an exceptional pain relief for migraine treatment [8]. [...]the most significant advantage to the rectal suppository is the guarantee of partial avoidance of the hepatic first pass effect as this helps to increase the bioavailability of drugs. The new addition in this work considered triflu the hydrophilic drug to be formulated in a fatty base such as the cocoa butter as our review to the suppository researches showed no study used a hydrophilic drug in a fatty base of suppository for prolonged action. [...]to investigate the aim of work; different formulations of triflu suppositories composed of cocoa butter as a base and loaded with different concentrations of span 60, tween 80, and PEG 400 separately. [...]the effect of the addition of span 60, tween 80, and PEG 400 to the cocoa butter suppositories on the release of triflu was examined and the best addition of surfactants that achieved the aim of work was investigated for further examinations by both the FTIR to check the possible changes of the triflu molecules and the thermal analysis using differential scanning calorimetry. 2.MATERIALS: