Spectrophotometric Determination of Carvedilol in Bulk drug and its Formulation by Multivariate Calibration Technique

[...]carvedilol is an antagonist of a1 and ß1, ß2 receptors1,2,3. There are many cardiovascular disorders like congestive heart failure, high blood pressure, myocardial infraction (MI) and ischemic heart disease (IHD) in which carvedilol is used in varying doses: 3.125mg. (7) where, Ax ^ sum of the...

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Veröffentlicht in:Research journal of pharmacy and technology 2020-02, Vol.13 (2), p.915-922
Hauptverfasser: Nayabaniya, Anant, Seetharaman, R, Lakshmi, K.S
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Sprache:eng
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Zusammenfassung:[...]carvedilol is an antagonist of a1 and ß1, ß2 receptors1,2,3. There are many cardiovascular disorders like congestive heart failure, high blood pressure, myocardial infraction (MI) and ischemic heart disease (IHD) in which carvedilol is used in varying doses: 3.125mg. (7) where, Ax ^ sum of the absorbance obtained and Kx ^ sum of intercepts of regression equations. [...]the concentration of the analyte 'x' in a solution can be calculated by using the equation: ... While checking the solubility of Carvedilol, it was found to be freely soluble in methanol with slight or no solubility in other solvents. [...]carvedilol, both standard drug and the formulation were solubilized in methanol yo obtain a solution of various concentration for analysis.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.5958/0974-360X.2020.00173.0