Hepatoprotective activity of Chloroform and Ethyl acetate extract of Dipteracanthus patulus against Paracetamol induced Hepatotoxicity in rats through Antioxidant mechanism

The earlier study reported that hepatoprotective activity leaves of DP, hence there is no report on hepatoprotective activity of whole plant of DP and the hepatoprotective phytoconsituents like lupeol, β-carotene, β-sitosterol and rutin are already reported in this plant material. [...]this current research is aimed to evaluate the hepatoprotective effect of whole plant of Dipteracanthus patulus. [...]the leaves of various species of Dipteracanthus were used in various infectious diseases Phytochemical analysis of DP showed the presence of lyoniresinol-9'-O-ß-D-glucoside, 5,5-dimethoxy-lariciresinol-9-O-ß glucopyranoside, ßsitosterol, lupeol, a-ethyl galactose, apiginin-7-Orutinoside, a-D-glucose, ß-D-glucose and ß-D-fructose Other phytochemical studies report the presence of ascorbic acid, phenolic compounds, tannin, lycopene, carotenoid and a-tocopherol in DP From our laboratory, we have quantitatively analysed compounds, ß- carotene and ß-sitosterol3,4. The earlier study reported that hepatoprotective activity leaves of DP, hence there is no report on hepatoprotective activity of whole plant of DP and the hepatoprotective phytoconsituents like lupeol, ßcarotene, ß-sitosterol and rutin are already reported in this plant material5,6. [...]this current research is aimed to evaluate the hepatoprotective effect of whole plant of DP. The estimation of Serum Glutamic Pyruvate Oxaloacetate (SGOT), Serum Glutamic Pyruvate Transaminase (SGPT), Serum Alkaline Phosphatase (ALP), serum urea, uric acid, creatinine, serum total cholesterol, total triglyceride, high-density lipoproteins (HDL)- cholesterol level and low-density lipoproteins (LDL) cholesterol level were done by using standard Enzymatic (Span Diagnostics, India) [18-21].