Method of obtaining of extract by the method of Modified Maceration

The method of obtaining of medicinal product in the form of Frangula alnus bark extract, obtained by water-alcohol extraction is characterized in that water-alcohol extraction of Frangula alnus bark is done by dividing the raw material into 3 equal parts, 40% ethyl alcohol is added to each part at a ratio of "raw materials - extractant" 1:10, and then the first part insist for 48 hours, the second - 12 hours, the third - 30 minutes in a boiling water bath; then the raw material is squeezed out, the extraction is settled for 2 days in the cold (at a temperature of 8 °C) for precipitate the ballast substances, then it is filtered out. [...]it is actual to develop an efficient method of obtaining of the extract of Frangula alnus bark for different dosage forms. In the long-wavelength region of the electron spectrum of the alkaline-ammonia solution of frangulin A, there is also a clear absorption maximum at 524 ± 2 nm (Fig. 2). [...]the value 524 nm can be used as the analytical wavelength, and the dominant antraglycoside, frangulin A, can serve as a standard sample, and in the absence of a standard in the calculation formula, the theoretical value of the specific e1% absorption index ( 1см) is 180 [6]. The table 1 presents the results of the quantitative content of total of anthracen derivatives in the extraction of Frangula alnus bark on ethyl alcohol 40% (1:10), depending on the method of production. [...]the most effective way to obtain a dense extract of Frangula alnus bark was the proposed modified maceration method, which is characterized by a higher yield of active compounds.