β-Carbolines: synthesis of harmane, harmine alkaloids and their structural analogs by thermolysis of 4-aryl-3-azidopyridines and investigation of their optical properties

β-Carbolines: synthesis of harmane, harmine alkaloids and their structural analogs by thermolysis of 4-aryl-3-azidopyridines and investigation of their optical properties

Interest in β-carbolines is caused by the biological activity of these compounds and the use of their fluorescent properties in the study of their interaction with DNA and other biological targets, as well as with drug delivery vehicles. A new general method for the synthesis of harmane, harmine, an...

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2020, Vol.56 (1), p.73-83
Hauptverfasser: Shuvalov, Vladislav Yu, Elisheva, Valeriya А., Belousova, Anastasiya S., Arshinov, Evgenii V., Glyzdinskaya, Larisa V., Vorontsova, Marina А., Chernenko, Sergei А., Fisyuk, Aleksander S., Sagitullina, Galina P.
Format: Artikel
Sprache:eng
Schlagworte:
Alkaloids
Analogs
Aromatic compounds
Biological activity
Chemistry
Chemistry and Materials Science
Drug delivery systems
Fluorescence
Optical properties
Organic Chemistry
Pharmacy
Synthesis
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Zusammenfassung:Interest in β-carbolines is caused by the biological activity of these compounds and the use of their fluorescent properties in the study of their interaction with DNA and other biological targets, as well as with drug delivery vehicles. A new general method for the synthesis of harmane, harmine, and their structural analogs by thermolysis of substituted 4-aryl-3-azidopyridines was developed, and their optical properties were studied.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-020-02625-4