Filling the Gap: A Correlation between Objective and Subjective Measures of Injectability
Various injectable biomaterials are developed for the minimally invasive delivery of therapeutics. Typically, a mechanical tester is used to ascertain the force required to inject these biomaterials through a given syringe‐needle system. However, currently there is no method to correlate the force m...
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| Veröffentlicht in: | Advanced healthcare materials 2020-03, Vol.9 (5), p.e1901521-n/a |
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| creator | Robinson, Thomas E. Hughes, Erik A. B. Bose, Aniruddha Cornish, Elizabeth A. Teo, Jun Y. Eisenstein, Neil M. Grover, Liam M. Cox, Sophie C. |
| description | Various injectable biomaterials are developed for the minimally invasive delivery of therapeutics. Typically, a mechanical tester is used to ascertain the force required to inject these biomaterials through a given syringe‐needle system. However, currently there is no method to correlate the force measured in the laboratory to the perceived effort required to perform that injection by the end user. In this article, the injection force (F) for a variety of biomaterials, displaying a range of rheological properties, is compared with the effort scores from a 50 person panel study. The maximum injection force measured at crosshead speed 1 mm s−1 is a good proxy for injection effort, with an R2 of 0.89. This correlation leads to the following conclusions: participants can easily inject 5 mL of substance for F < 12 N; considerable effort is required to inject 5 mL for 12 N < F < 38 N; great effort is required and 64 N. These values may be used by developers of injectable biomaterials to make decisions about formulations and needle sizes early in the translational process.
The force required to inject a range of biomaterials with a mechanical tester is correlated with the perceived effort required by 50 participants to perform these injections. This correlation may be used to inform decisions during research and development of biomaterials designed for injection. |
| doi_str_mv | 10.1002/adhm.201901521 |
| format | Article |
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The force required to inject a range of biomaterials with a mechanical tester is correlated with the perceived effort required by 50 participants to perform these injections. This correlation may be used to inform decisions during research and development of biomaterials designed for injection.]]></description><identifier>ISSN: 2192-2640</identifier><identifier>EISSN: 2192-2659</identifier><identifier>DOI: 10.1002/adhm.201901521</identifier><identifier>PMID: 31977153</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>alginate ; Biomaterials ; Biomedical materials ; cement ; Correlation analysis ; Humans ; Injectability ; Injection ; Injections ; Mechanical Phenomena ; Needles ; Rheological properties ; Rheology ; testing methods ; Viscosity</subject><ispartof>Advanced healthcare materials, 2020-03, Vol.9 (5), p.e1901521-n/a</ispartof><rights>2020 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2020 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4461-4f199cba5058812b3cc9351b737a8fccdadcb3f9296ffb90334f3a1587c22643</citedby><cites>FETCH-LOGICAL-c4461-4f199cba5058812b3cc9351b737a8fccdadcb3f9296ffb90334f3a1587c22643</cites><orcidid>0000-0002-0003-2286</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadhm.201901521$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadhm.201901521$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31977153$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Robinson, Thomas E.</creatorcontrib><creatorcontrib>Hughes, Erik A. B.</creatorcontrib><creatorcontrib>Bose, Aniruddha</creatorcontrib><creatorcontrib>Cornish, Elizabeth A.</creatorcontrib><creatorcontrib>Teo, Jun Y.</creatorcontrib><creatorcontrib>Eisenstein, Neil M.</creatorcontrib><creatorcontrib>Grover, Liam M.</creatorcontrib><creatorcontrib>Cox, Sophie C.</creatorcontrib><title>Filling the Gap: A Correlation between Objective and Subjective Measures of Injectability</title><title>Advanced healthcare materials</title><addtitle>Adv Healthc Mater</addtitle><description><![CDATA[Various injectable biomaterials are developed for the minimally invasive delivery of therapeutics. Typically, a mechanical tester is used to ascertain the force required to inject these biomaterials through a given syringe‐needle system. However, currently there is no method to correlate the force measured in the laboratory to the perceived effort required to perform that injection by the end user. In this article, the injection force (F) for a variety of biomaterials, displaying a range of rheological properties, is compared with the effort scores from a 50 person panel study. The maximum injection force measured at crosshead speed 1 mm s−1 is a good proxy for injection effort, with an R2 of 0.89. This correlation leads to the following conclusions: participants can easily inject 5 mL of substance for F < 12 N; considerable effort is required to inject 5 mL for 12 N < F < 38 N; great effort is required and <5 mL can be injected for 38 N < F < 64 N; and materials are entirely non‐injectable for F > 64 N. These values may be used by developers of injectable biomaterials to make decisions about formulations and needle sizes early in the translational process.
The force required to inject a range of biomaterials with a mechanical tester is correlated with the perceived effort required by 50 participants to perform these injections. This correlation may be used to inform decisions during research and development of biomaterials designed for injection.]]></description><subject>alginate</subject><subject>Biomaterials</subject><subject>Biomedical materials</subject><subject>cement</subject><subject>Correlation analysis</subject><subject>Humans</subject><subject>Injectability</subject><subject>Injection</subject><subject>Injections</subject><subject>Mechanical Phenomena</subject><subject>Needles</subject><subject>Rheological properties</subject><subject>Rheology</subject><subject>testing methods</subject><subject>Viscosity</subject><issn>2192-2640</issn><issn>2192-2659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNqFkLtPwzAQxi0Eoqh0ZUSWmFP8iJOYrSr0IbXqQBcmy3Zs6ipNip1Q9b8nVUsYueUe-t13ug-AB4yGGCHyLPPNbkgQ5ggzgq_AHcGcRCRh_LqrY9QDgxC2qI2E4STDt6BHMU9TzOgd-Ji4onDlJ6w3Bk7l_gWO4Ljy3hSydlUJlakPxpRwpbZG1-7bQFnm8L3p2qWRofEmwMrCeXmaSuUKVx_vwY2VRTCDS-6D9eRtPZ5Fi9V0Ph4tIh3HCY5iiznXSjLEsgwTRbXmlGGV0lRmVutc5lpRywlPrFUcURpbKjHLUk3a72gfPJ1l9776akyoxbZqfNleFISmiMY8TlBLDc-U9lUI3lix924n_VFgJE5eipOXovOyXXi8yDZqZ_IO_3WuBfgZOLjCHP-RE6PX2fJP_Aezf39d</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Robinson, Thomas E.</creator><creator>Hughes, Erik A. 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B. ; Bose, Aniruddha ; Cornish, Elizabeth A. ; Teo, Jun Y. ; Eisenstein, Neil M. ; Grover, Liam M. ; Cox, Sophie C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4461-4f199cba5058812b3cc9351b737a8fccdadcb3f9296ffb90334f3a1587c22643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>alginate</topic><topic>Biomaterials</topic><topic>Biomedical materials</topic><topic>cement</topic><topic>Correlation analysis</topic><topic>Humans</topic><topic>Injectability</topic><topic>Injection</topic><topic>Injections</topic><topic>Mechanical Phenomena</topic><topic>Needles</topic><topic>Rheological properties</topic><topic>Rheology</topic><topic>testing methods</topic><topic>Viscosity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Robinson, Thomas E.</creatorcontrib><creatorcontrib>Hughes, Erik A. B.</creatorcontrib><creatorcontrib>Bose, Aniruddha</creatorcontrib><creatorcontrib>Cornish, Elizabeth A.</creatorcontrib><creatorcontrib>Teo, Jun Y.</creatorcontrib><creatorcontrib>Eisenstein, Neil M.</creatorcontrib><creatorcontrib>Grover, Liam M.</creatorcontrib><creatorcontrib>Cox, Sophie C.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Immunology Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><jtitle>Advanced healthcare materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Robinson, Thomas E.</au><au>Hughes, Erik A. B.</au><au>Bose, Aniruddha</au><au>Cornish, Elizabeth A.</au><au>Teo, Jun Y.</au><au>Eisenstein, Neil M.</au><au>Grover, Liam M.</au><au>Cox, Sophie C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Filling the Gap: A Correlation between Objective and Subjective Measures of Injectability</atitle><jtitle>Advanced healthcare materials</jtitle><addtitle>Adv Healthc Mater</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>9</volume><issue>5</issue><spage>e1901521</spage><epage>n/a</epage><pages>e1901521-n/a</pages><issn>2192-2640</issn><eissn>2192-2659</eissn><abstract><![CDATA[Various injectable biomaterials are developed for the minimally invasive delivery of therapeutics. Typically, a mechanical tester is used to ascertain the force required to inject these biomaterials through a given syringe‐needle system. However, currently there is no method to correlate the force measured in the laboratory to the perceived effort required to perform that injection by the end user. In this article, the injection force (F) for a variety of biomaterials, displaying a range of rheological properties, is compared with the effort scores from a 50 person panel study. The maximum injection force measured at crosshead speed 1 mm s−1 is a good proxy for injection effort, with an R2 of 0.89. This correlation leads to the following conclusions: participants can easily inject 5 mL of substance for F < 12 N; considerable effort is required to inject 5 mL for 12 N < F < 38 N; great effort is required and <5 mL can be injected for 38 N < F < 64 N; and materials are entirely non‐injectable for F > 64 N. These values may be used by developers of injectable biomaterials to make decisions about formulations and needle sizes early in the translational process.
The force required to inject a range of biomaterials with a mechanical tester is correlated with the perceived effort required by 50 participants to perform these injections. This correlation may be used to inform decisions during research and development of biomaterials designed for injection.]]></abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31977153</pmid><doi>10.1002/adhm.201901521</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-0003-2286</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | alginate Biomaterials Biomedical materials cement Correlation analysis Humans Injectability Injection Injections Mechanical Phenomena Needles Rheological properties Rheology testing methods Viscosity |
| title | Filling the Gap: A Correlation between Objective and Subjective Measures of Injectability |
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