Filling the Gap: A Correlation between Objective and Subjective Measures of Injectability

Various injectable biomaterials are developed for the minimally invasive delivery of therapeutics. Typically, a mechanical tester is used to ascertain the force required to inject these biomaterials through a given syringe‐needle system. However, currently there is no method to correlate the force measured in the laboratory to the perceived effort required to perform that injection by the end user. In this article, the injection force (F) for a variety of biomaterials, displaying a range of rheological properties, is compared with the effort scores from a 50 person panel study. The maximum injection force measured at crosshead speed 1 mm s−1 is a good proxy for injection effort, with an R2 of 0.89. This correlation leads to the following conclusions: participants can easily inject 5 mL of substance for F < 12 N; considerable effort is required to inject 5 mL for 12 N < F < 38 N; great effort is required and 64 N. These values may be used by developers of injectable biomaterials to make decisions about formulations and needle sizes early in the translational process. The force required to inject a range of biomaterials with a mechanical tester is correlated with the perceived effort required by 50 participants to perform these injections. This correlation may be used to inform decisions during research and development of biomaterials designed for injection.