Association of elevated interleukin-33 serum levels with tumorstages in patients with prostate cancer

Inflammation has a prominent role in cancer development and interleukin (IL)-33 has both inflammatory and anti-inflammatory properties. The aim of this study was to measure IL-33 quantities and genetic alterations in the rs1929992 SNP within IL-33 gene in patients with prostate cancer (PC). This inv...

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Veröffentlicht in:	European Cytokine Network 2019-12, Vol.30 (4), p.144-150
Hauptverfasser:	Chatrabnous, Nazanin, Jafarzadeh, Abdollah, Ghaderi, Abass, Ariafar, Ali, Aminizadeh, Najmeh, Ghassabi, Farzaneh, Nemati, Maryam
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Anti-inflammatory agents Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Biomarkers, Tumor - immunology Case-Control Studies Cytokines Gene Frequency Genetic Predisposition to Disease Genotype & phenotype Genotypes Genotyping Humans Inflammation Interleukin-33 - blood Interleukin-33 - genetics Interleukin-33 - immunology Male Middle Aged Neoplasm Grading Neoplasm Staging Odds Ratio Polymerase chain reaction Polymorphism, Single Nucleotide Prostate cancer Prostatic Neoplasms - blood Prostatic Neoplasms - diagnosis Prostatic Neoplasms - genetics Prostatic Neoplasms - immunology Restriction fragment length polymorphism Risk Serum levels Single-nucleotide polymorphism
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Zusammenfassung:	Inflammation has a prominent role in cancer development and interleukin (IL)-33 has both inflammatory and anti-inflammatory properties. The aim of this study was to measure IL-33 quantities and genetic alterations in the rs1929992 SNP within IL-33 gene in patients with prostate cancer (PC). This investigation was conducted on blood specimens from 150 newly diagnosed PC patients and 150 healthy age-matched controls. Serum IL-33 measurements and genotyping were performed by ELISA and PCR-RFLP, respectively. Elevated IL-33 quantities were detected in PC patients compared with controls (P
ISSN:	1952-4005 1148-5493 1952-4005
DOI:	10.1684/ecn.2019.0438